Genetics and Jazz: The Two Sides to Emily Vohralik

By Kristina Fidanovski

Emily Vohralik

Emily, like many scientists, leads a double life. She doesn’t begin with that though. When she sits down for this interview, she has an easy smile and ready words to set me at ease (I’ve never interviewed anyone before), and at first she tells me about molecular genetics and cell biology. The Jazzercise comes later.

By day, Emily works on getting her PhD. Where that will take her, she’s not too sure yet. But for now, she looks at how genes can affect your metabolism through your immune system. Specifically, she’s looking at the genes inside a type of immune cell – the eosinophil – which lives inside fat and . There’s been a lot of hype around beige and brown fat recently, mostly because it’s a type of fat that burns energy. Some people have it, some people don’t. And that’s pretty exciting to think about in terms of how these cells could be activated and used as an obesity treatment. Emily says that the hype isn’t necessarily wrong or misinformed, it’s just early: we’re not there yet. Her work is on the fundamental end, she’s working on establishing the basic facts about eosinophils, their genes and how they interact with fat cells.

An Average Day in the Life of Emily: Molecular Geneticist
The Dreaded Commute Check emails and get the day started.
Morning Lab Time! Working with bacteria to grow some DNA and then extract it.

Outreach Activity: A fun 20 minutes of pretending not to be cold for a Women in STEAM photoshoot (a collaboration between women in science and art to capture the image of all types of scientists for a photo exhibit).

Lunch Important networking time… that is, lunch with a couple of the lab buddies.
Afternoon More lab time, this time to prepare the DNA for sequencing and send it off.

Some computer time analysing data, catching up on the latest in the field, or putting off working on those presentation slides you really need to do.

Evening Freedom: for musical and athletic pursuits!
Emily in the tissue culture hood preparing to feed her cells.

But how did Emily come to be labouring away on a PhD anyway? She says that in high school she was just picking all the subjects she enjoyed. And those subjects happened to be chemistry, physics and biology (with some maths and English thrown in), even though her teachers were saying “Isn’t that too much science?” Emily didn’t think so. At university she did some general science and got really interested in molecular cell biology. She got more and more engrossed as each year passed until her third year conversations with PhD students hooked her into doing an honours project. It was in the same group she’s currently working in. When her honours year was coming to a close she says, “I felt like I had only just scratched the surface of my project.” So it felt natural to her to keep going and really dig into the fascinating world of ‘immunometabolism’.

Emily showing an experiment to an honours student, Annalise: labelling eosinophils with fluorescent tags and then analysing them with flow cytometry.

It seems to be going well for her. She’s a recipient of the prestigious Scientia Scholarship, though she’s too modest to mention it. And she already has an international conference under her belt. Last year she presented a poster at an ‘Immunometabolism’ conference in Aspen, Colorado. She says it was really cool to finally meet the people whose names you see on papers. She also likes how easy it is to share ideas when you’ve all been brought together like that. This year she’ll be travelling again for an ‘Eosinophil’ conference in Portland, Oregon. She’s looking forward to it, not just because the travel part is fun, but also because she feels that meeting other researchers expands your thinking in ways that no other experience can.

Finally, I get around to asking her who she is when the lab coat comes off. The answer is “Jazzercise! The original dance fitness.” I learn that it was started 50 years ago and involves dancing to songs for exercise, with strength training at the end to make sure you really feel it in the morning. Emily likes exploring that totally different side of herself and she’s even been an instructor since last July. It’s certainly an unexpected and totally brilliant answer. I’m fascinated. It’s almost an afterthought when I also learn that she plays clarinet in the Kuringai Youth Orchestra. She is a hidden wealth of talents.

In the end I ask her about the UNSW Women in Maths and Science Champions Program. “It was always something that I wanted to try,” she says – interacting, connecting with young girls who might one day come to love science. She thinks that it’s sad a lot of young girls might not even consider science. “We’ve all been there, if we can be inspiring to them that’s pretty cool.” She feels that being a scientist is about more than just the science that happens in the lab, “We have to be communicators too.”

Follow Emily on twitter @EVohralik

Follow Kristina on twitter @Kris_Fidanovski

Band-aid for a Broken Heart: Kristina Fidanovski’s Adventures with Conjugated Polymers

By Raisa Rafique

It was love at first sight for Kristina when she found her current research project at UNSW after multiple lab placement programs. Since then every day for her has been something like a wild quest into unlocking the secrets of the complex world of conductive polymers. Her research as an organic chemist strives to tame these somewhat uncooperative substances into forming therapeutic patches for patients suffering from heart-attacks. When she’s not in the lab pursuing these ‘funky plastics’, Kristina can be found either curled up cosily with a nice little book, having fun with friends, playing trombone in a band or travelling far and wide to her heart’s content.  

“I knew from a very young age that I wanted to do research,” Kristina Fidanovski’s eyes glittered fondly as she started telling her story.

Kristina’s journey began in Perth, at the University of Western Australia, where she was trying to figure out which road in science excited her more- physics or chemistry. While she had genuine love and appreciation for both, she became particularly taken with the idea of various medical applications of chemistry while working with antibiotics during her Honours program. Finally, her journey brought her to UNSW where she came across her current PhD project and felt that instant spark, “Yes! This is what I want to do!!”

So what is it about her work that excites her so much? Kristina is working to develop a conductive patch or ‘band-aid’ capable of restoring function to a damaged heart that has suffered a heart-attack. For this, she needs to work with polymers, a kind of multi-unit substance made of millions of repeating core individual units called monomers (plastic, resin etc. are some examples). During a heart-attack, part of the heart muscle dies and that section loses its conductivity and becomes scar tissue, which doesn’t transmit electric signals well. A biologically compatible polymer patch capable of conducting electricity can therefore help the injured heart heal by synchronously transmitting signals throughout the organ.

Currently the non-conductive elements of this patch have been described. The natural polymer mixed with a light sensitive dye can be stuck on to the target tissue with a green light. This is where Kristina’s work comes in, because she has to explore conductive polymers and try to make sure they stay conductive where others would lose their conductivity in the biological environment. A typical day in the lab would find her immersed in cooking up these polymers and characterising their properties for around 4-8 hours with the rest of her time spent at the computer analysing her data or writing. “There are times when I actually find it a bit difficult to stop, because I love my work and it feels too good being in the lab…and then I end up working for 8-12 hours in a day, which I will definitely regret afterwards!” Kristina feels that a good work-life balance is definitely important, and tries to de-stress by doing yoga at a set hour during the evening.

Kristina has experienced some major low points in her journey due to health issues, but she refused to be defeated by her circumstances. Despite suffering from a chronic autoimmune illness, she continues to pursue her career goals like a true fighter, doing what she loves to do every day with renewed vigour and strength. She gratefully acknowledges the support she received from everyone including her parents, friends, supervisory team and also the various support services within UNSW, “I want people to know that even if you run into a stumbling block, there’s always help around the corner. So don’t give up and don’t be disappointed, give yourself the flexibility to try a few new things.”

As a UNSW woman champ, Kristina was very excited to meet all the esteemed ladies in science. “I feel lucky to be in a research group comprised of female colleagues, but when I look up ranks in material science there’s only less than a handful of women!” she said. Kristina feels being a role model isn’t just about being someone distant or untouchable, it should be someone people can easily talk to—“I wanted to be that person: approachable, admired and acknowledged for my work, but if anyone ever needs to chat or has a question, I’d be the one they could turn to. I’d like to be part of that kind of support network.”

When she’s not busy being a researcher, Kristina likes to read– “maybe a little bit too much!” she adds playfully. Her favourite author is Terry Pratchett, whom she really appreciates for his mastery of the English language. “Stories are a really important part of the human experience,” she says, and books create something like a welcome escape in her busy life. Nevertheless, she is a very social person, enjoying the company of friends and family from time to time. A former Taekwondo black belt, Kristina also loves dancing and playing the trombone in a local community band. In future, she wants to continue doing science communication, with particular interest in medical science liaison projects for industries. “Science affects pretty much every aspect of every single person’s life, it’s our responsibility as scientists to explain it to everyone properly. Also, I think science is so great, I’d really like it for other people to think it was great too!” she concludes on a hopeful note.

FollowKristina on Twitter (@Kris_Fidanovski)

Follow Raisa on Twitter (@RaisaBangladesh)