Climate science for a better world: meet Rachael Isphording

By Inna Osmolovsky

Rachael Isphording is a Scientia PhD candidate in the Climate Change Research Center at UNSW (affiliated with the ARC Centre of Excellence for Climate Extremes). She studies climate science and climate adaptation. These fields focus on understanding how and why Earth’s climate has changed in the past and how it could change in the future. The research involves close work with policymakers, stakeholders and communities, helping better prepare for high-impact, catastrophic weather and climate events. Rachael’s research focuses on understanding how well high-resolution, regional climate models simulate rainfall across Australia, on one hand. On the other, she looks into how this knowledge can be leveraged to improve stakeholder decision-making across sectors. With the official announcement of a third, consecutive, year of La Niña in Australia, her findings are helping local communities to anticipate, prepare and adapt to extreme rain events.

Her passion for climate adaptation research stems largely from her childhood experiences, living through Hurricane Ivan (2004) and Hurricane Katrina (2005). Growing up in Alabama, on the coast of the Gulf of Mexico, she witnessed firsthand the detrimental impacts of extreme events and their impact on the communities around her. For her, it’s not just about understanding how weather patterns and extreme events might change in the context of climate change. As a self-described humanitarian, she’s also driven by the “people” side of climate science: what does it mean for us – society – and our overall well-being? What can we do to make things better for future generations?

Her journey into academia started at Embry-Riddle Aeronautical University. There, she first aspired to become a pilot and research meteorologist, flying into hurricanes to collect data. During the completion of her meteorology degree, she took an Environmental Security course which changed the trajectory of her career.  The course focused on how climate change affects human security, helping her realize where her passion truly lies.

During the completion of her bachelor’s Rachael interned for the NASA DEVELOP Program. She was partnered with decision-makers in ‘Mobile (Alabama) Area Water and Sewer System’ company. Her role involved helping to predict how the future growth of the city could affect the local drinking water reservoir. This directly affected water quality for the local community, including Rachael’s grandparents. Rachael was empowered by the fact that the results of her research—as an undergraduate student—would inform actual decision-making to help her local communities.

Sadly, not all of Rachael’s experiences in academia were positive. After graduating with her bachelor’s and interning with the U.S. Department of Energy (DOE), Rachael pursued a PhD at a U.S. university. The working environment during that time wasn’t very supportive or healthy. Despite her impressive achievements and dedication to pursuing a career in science, she started to lose confidence in her abilities and struggled with her mental health. Rachael realized how toxic the environment was and bravely left the program with a master’s degree.

What helped her through this difficult time was a group of fellow graduate students; they supported each other through the tough times and continue to support each other to this day. They also were the ones to encourage Rachael during her challenging job search following the completion of her master’s degree. After nearly a year of rejections, she was finally offered an internship with a defense contractor at NASA. This internship helped rebuild Rachael’s confidence in herself and her abilities. The program also helped her to remember her lifelong dreams of becoming a scientist and using her knowledge to help people. After completing this program, Rachael returned to the DOE where she worked for over two years. This was when she applied and was accepted into the Scientia PhD program at UNSW, researching climate change and water security – her dream research.

A picture says 1000 words! Rachael studies rainfall across Australia

Nowadays, a typical day in her life—while not traveling abroad for exciting workshops, conferences, and collaborations—includes exploring how well regional climate models simulate rainfall and how rainfall patterns across Australia may change in the future. She works with local stakeholders to understand the challenges they face and determine how climate information can help to inform their decision-making.

While traveling to South Africa for a World Meteorological Organization (WMO) Workshop (September 2022), Rachael worked with fellow climate scientists, Nicholas Herold, and Jorge Vazquez-Aguirre, to help sector leaders from different African countries analyze historical climate data to include in their climate adaptation plans

Understanding rainfall is surprisingly complex – where will it rain? For how long? How much rain will fall, and when? What are the diurnal rainfall cycles? What will rain patterns look like during extreme droughts? Or extreme rainfall? For her research, Rachael is analyzing over 1 terabyte of observational and climate model data. To manage the analyses of such large quantities of data, Rachael works on the Australian supercomputer.

Rachael presents her research at the Swiss Climate Summer School in Grindelwald, Switzerland (August 2022)

Rachael says that she is very grateful to have found such a supportive research department and supervisors at UNSW.  Her all-female supervisory team is a major source of inspiration and encouragement for her as she continues to grow and learn, professionally and personally. She also takes full advantage of being a PhD student – acknowledging that she is still learning and embraces asking others for help to expand her skillset and expertise.

In her role as a Women in Science and Maths champion, Rachael hopes to inspire other women and young girls to pursue careers in STEM. She hopes that by telling the story of her unique career path—the hardships and successes— she would help others to embark and persevere through their own journey of realizing their dreams. Rachael hopes to inspire young girls to believe that their only limitation is their own ambition.

Follow Rachael on Twitter!

Functionalising materials with protein nanowires, from tissue engineering to biobattery: Meet Nga Lam

By Vina Putra

Nga is a Scientia PhD Candidate at the School of Biotechnology and Biomolecular Sciences (BABS), UNSW. Her research focuses on engineering proteins with metal ions to create nanosized wires that can be used to provide electroconductivity and to functionalise materials for biomedical and energy applications. Nga is passionate about biomaterials research, in promoting the work of women and providing support for women in science. 

Nga’s journey in science has cultivated her passion for biomaterials research

For Nga Lam, spending time in the lab and being constantly fascinated by small findings from her experiments are the key to thrive in science. As a PhD candidate, Nga studies a specific type of protein that carries metal ions, called metalloproteins. She engineers, synthesises and characterises protein for the spatial organisation of metalloproteins to create nanowires. Ultimately, she aims to use the nanowires to functionalise materials where electroconductivity is desired such as in neural tissue-engineered construct or to provide source of bioenergy, the bio-battery.

Nga’s protein nanowire relies on the electron transfer through metal ions that are present in the centre of metalloproteins. When these proteins are spatially organised in series, these metal ions could generate electronically conductive signals as electrons go through the system from one end to the other. “It is exciting to be able to see the electrons travel through my protein nanowire”, Nga explained in awe. This could be the first step to revolutionize electronic devices by using biological system.

But how do we arrange the proteins in such a way that they can exhibit electroconductivity? Nga’s work starts all the way from designing the gene and inserting it into bacteria to sufficiently produce the desired metalloproteins. Synthesising metalloproteins in bacterial cells is challenging, therefore, Nga has to optimise conditions for the expression of proteins with different metal ions such as heme, Iron-sulfur (Fe-S) or copper. She then aligns metalloproteins along protein filaments and engineers the terminal site of nanowires to be able to incorporate them into enzymes (molecules that can catalyse biochemical reactions); one kind which serves as electron donor and the other as electron acceptor. “This way catalytic reactions of enzymes can drive electrons hopping from terminus to the opposite site without the need to apply external voltage. It’s a source of energy from biocatalysis”.

Nga in her lab at the School of Biotechnology and Biomolecular Sciences (BABS), UNSW

Now, three years into her PhD, Nga looks back through her journey in science and shares with us what she has learned from her experience as a female scientist.

Nga grew up in the centre of Mekong delta, Can Tho city, Vietnam. She started off her journey in science as she pursued a bachelor program in advanced biotechnology in Can Tho University, Vietnam, with a joined curriculum from Michigan State University. Her passion for science grew bigger as soon after completing her bachelor studies, she worked in the research and development team in a Japanese-originated baseball glove company called Trion. She studies various types of feathers and their mechanical properties to create baseball gloves with specific functions. It is during this work in developing materials for baseball gloves that inspired her to further her career as a biomaterials scientist. She then moved to Thailand and pursued a master’s degree by research at Kasetsart University, where she studied cellulose from agricultural waste such as sugarcane bagasse for tissue engineering scaffolds. Nga’s master research revolved around cellulose nanoparticles and developing ways to improve the functionality of materials.

After graduating from her master’s studies, Nga became a research assistant in the same group where she completed her master’s research. During this time, her career in science really took off as she had the opportunity to explore and incorporate bioactive materials. In particular, she developed methods to produce and incorporate hydroxyapatite (HA) as a bioactive component in the nanocellulose scaffold. Her recent publication reports the novel method for homogenisation of HA using cellulose nanocrystals, which promotes osteoblast (bone cells) proliferation and differentiation or specialisation. Nga also gained leadership experience as she worked with honours students in the lab at Kasetsart in utilising nanocellulose from plants and bacteria, in which she tested her method of functionalisation with HA for tissue engineering. Her work resulted in 11 publications within the span of 4 years.  With years of experience in biomaterials engineering, she came to learn that the lack of recognition (protein) for biological cells has been the challenge in the functionality of materials, and this became her motivation to work on protein-functionalised biomaterials.

Nga at Kasetsart University, Bangkok, where she completed her master’s degree and worked as a research assistant

As a woman in Science, Nga opened up about the challenges that she encountered throughout her journey in research while living in different countries. One of the biggest challenges for her was as she shared, “There would always be people or situations that would try to stop you from achieving your goals or be unsupportive”.  Her advice for women facing obstacles is “to keep doing it for science, show the highest commitment and love in the science you’re doing, and others won’t matter”.

As a UNSW Woman in Science Champion, Nga visions herself to hone her leadership skills in the program to one day become a research leader who empowers and supports women in getting access to the knowledge and training they seek. She also looks forward to taking part in promoting women’s achievement in science and hopes that the next generation of women scientists strongly cultivate their love for science – love is the greatest motivator.

Check out Nga’s scientific work here and follow her on twitter @Nga_TLam